2020 has been a year of significant interruptions across our worlds, the largest being the global pandemic. The spread of the COVID-19 virus has revealed both our profound global entanglement and divergences in local capacities to prevent or contain it. Competing conceptions of public health and social well-being have affected the way that we live together—interrupting global exchange, urban and rural relations, international collaborations, and education at all levels—and have resurfaced questions and concerns about civil discourse, race relations, democratic practices, and the operations of academic life. The interruption of our ability to convene in person is an occasion to recognize the many ways that humanities centers and institutes have engaged with this rupture in its varied scales and contexts, and to reflect on the concepts and formations that have surfaced through it.